RSL3

Term ID

CHEBI:173109

Synonyms

(1S,3R)-RSL3
methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,4a,9,9a-hexahydro-1H-beta-carboline-3-carboxylate
ras-selective lethal small molecule 3

Definition

A β-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-β-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme.

References

cas:1219810-16-8
kegg.compound:C21479
pubmed:18355723
pubmed:27588473
pubmed:28837253
pubmed:30339884
pubmed:30524291
pubmed:31445705
pubmed:31581313
pubmed:31761326
pubmed:31819616
pubmed:31906464
pubmed:32067993
pubmed:32368394
pubmed:32457486
pubmed:32678313
pubmed:33030956
pubmed:33038905
pubmed:33156626
pubmed:33211827
pubmed:33245979
pubmed:33290842
pubmed:33362556
pubmed:33404288
pubmed:33483372
pubmed:33544270
pubmed:33611811
pubmed:33863873
pubmed:33892112
pubmed:33931597
pubmed:34015760

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from RSL3

Phenotype where environments contain RSL3

Phenotype modified by environments containing RSL3

Phenotype affecting RSL3

Human Disease Model