Search Ontology:
ChEBI
ferroptocide
- Term ID
- CHEBI:173106
- Synonyms
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- (2S,3aS,4S,5R,7R,8S,8aS,9R)-5-(1,3-dioxo-2-phenyl-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-6-yl)-2,8a-dihydroxy-4,8,9-trimethyl-1-oxooctahydro-1H-3a,8-propanoazulen-7-yl chloroacetate
- FTC
- Definition
- A triazolopyridazine that is 5,8-dihydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione substituted by phenyl and (2S,3aS,4S,5S,7R,8S,8aS,9R)-7-[(chloroacetyl)oxy]-2,8a-dihydroxy-4,8,9-trimethyl-1-oxooctahydro-1H-3a,8-propanoazulen-5-yl groups at positions 2 and 6, respectively. It is a small molecule inhibitor of thioredoxin, a key component of the antioxidant system in cells. It induces rapid ferroptotic death in immortalized cancer cell lines and primary cancer cells from patients.
- References
-
- PMID:31086302
- Patent:WO2020210158
- Reaxys:34613802
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 8 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from ferroptocide
Phenotype where environments contain ferroptocide
Phenotype modified by environments containing ferroptocide
Human Disease Model