Search Ontology:
ChEBI
GSK343
- Term ID
- CHEBI:167693
- Synonyms
-
- 1-isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1H-indazole-4-carboxamide
- GSK 343
- GSK-343
- Definition
- A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).
- References
-
- cas:1346704-33-3
- patent:CA2798622
- pubmed:26973856
- pubmed:27278257
- pubmed:28675010
- pubmed:28925507
- pubmed:29228694
- pubmed:30365505
- pubmed:31572509
- pubmed:31651209
- pubmed:31720078
- pubmed:32222493
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from GSK343
Phenotype where environments contain GSK343
Phenotype modified by environments containing GSK343
Phenotype affecting GSK343
Human Disease Model