Search Ontology:
ChEBI
SCH772984
- Term ID
- CHEBI:167670
- Synonyms
-
- (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide
- (3R)-1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide
- SCH 772984
- SCH-772984
- Definition
- A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties.
- References
-
- cas:942183-80-4
- lincs.smallmolecule:LSM-45224
- pdb-ccd:38Z
- pdb-ccd:F3Z
- pubmed:23847348
- pubmed:25142146
- pubmed:25195011
- pubmed:26832798
- pubmed:27275127
- pubmed:28781955
- pubmed:29193645
- pubmed:29262554
- pubmed:29775310
- pubmed:30915617
- pubmed:31055884
- pubmed:31311868
- pubmed:32652503
- pubmed:32821122
- pubmed:33105944
- pubmed:33151174
- pubmed:33231464
- pubmed:33258389
- pubmed:33595872
- pubmed:33692846
- pubmed:33706642
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from SCH772984
Phenotype where environments contain SCH772984
Phenotype modified by environments containing SCH772984
Phenotype affecting SCH772984
Human Disease Model