Search Ontology:
ChEBI
GDC-0623
- Term ID
- CHEBI:167659
- Synonyms
-
- 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
- 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
- G 868
- Definition
- A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.
- References
-
- CAS:1168091-68-6
- Chemspider:30687718
- DrugBank:DB11982
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 7 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from GDC-0623
Phenotype where environments contain GDC-0623
Phenotype modified by environments containing GDC-0623
Phenotype affecting GDC-0623
Human Disease Model