thiolutin

Term ID

CHEBI:156450

Synonyms

6-acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
acetopyrrothin
acetopyrrothine
N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide

(all 6)

Definition

A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases.

References

(all 23)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: acetamides dithiolopyrrolone antibiotic

acetamides dithiolopyrrolone antibiotic Show first 5 Terms
has_functional_parent: holomycin

holomycin Show first 5 Terms
has_role: angiogenesis inhibitor antibacterial agent antifungal agent antineoplastic agent bacterial metabolite ... Show All 10 Terms

angiogenesis inhibitor antibacterial agent antifungal agent antineoplastic agent bacterial metabolite chelator EC 2.7.7.6 (RNA polymerase) inhibitor marine metabolite protein synthesis inhibitor toxin Show first 5 Terms

Phenotype

Phenotype resulting from thiolutin

Phenotype where environments contain thiolutin

Phenotype modified by environments containing thiolutin

Human Disease Model