G-15

Term ID

CHEBI:156295

Synonyms

(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
G 15
G15

Definition

An organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline substituted by a 6-bromo-1,3-benzodioxol-5-yl group at position 4 (the 3aS,4R,9bR-stereoisomer). It is a high affinity and selective GPER1 receptor antagonist (Ki = 20 nM) which inhibits the anti-depressive effects of estrogen in vivo.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzodioxole organic heterotricyclic compound organobromine compound

benzodioxole organic heterotricyclic compound organobromine compound Show first 5 Terms
has_role: antineoplastic agent G-protein-coupled receptor antagonist

antineoplastic agent G-protein-coupled receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from G-15

Phenotype where environments contain G-15

Phenotype modified by environments containing G-15

Human Disease Model