tilivalline

Term ID

CHEBI:156292

Synonyms

• (11S,11aS)-9-hydroxy-11-(1H-indol-3-yl)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
• (7S,8S)-11-hydroxy-8-(1H-indol-3-yl)-3,9-diazatricyclo[8.4.0.0(3,7)]tetradeca-1(10),11,13-trien-2-one
• epitilivalline

Definition

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells.

References

• cas:80279-24-9
• pubmed:11672297
• pubmed:25057966
• pubmed:25157164
• pubmed:28970173
• pubmed:28972161
• pubmed:28977734
• pubmed:29389112
• pubmed:29596433
• pubmed:30808763
• pubmed:31717457
• pubmed:7666357
• pubmed:7710637

Ontology

ChEBI  ( EBI )

Resources

CTD