CGP-42112A

Term ID

CHEBI:147302

Synonyms

• CGP 42112A
• CGP-42112
• CGP-42112A
• CGP42112A
• N(6)-[[(phenylmethoxy)carbonyl]-L-Arg-]-N(2)-[[(pyridin-3-yl)carbonyl]-L-Tyr-]-L-Lys-L-His-L-Pro-L-Ile-OH
• N(6)-{N(2)-[(benzyloxy)carbonyl]-L-arginyl}-N(2)-[N-(pyridin-3-ylcarbonyl)-L-tyrosyl]-L-lysyl-L-histidyl-L-prolyl-L-isoleucine
• N(6)-{N(2)-[(benzyloxy)carbonyl]-L-arginyl}-N(2)-[N-(pyridine-3-carbonyl)-L-tyrosyl]-L-lysyl-L-histidyl-L-prolyl-L-isoleucine
• Nalpha-nicotinoyl-Tyr-(Nalpha-Cbz-Arg)-Lys-His-Pro-Ile

Definition

A hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N²-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT₂ receptor) agonist.

References

• cas:127060-75-7
• pubmed:11454929
• pubmed:12689346
• pubmed:14615403
• pubmed:16380464
• pubmed:21803946
• pubmed:23201312
• pubmed:24712284
• pubmed:24957202
• pubmed:25014541
• pubmed:25100281
• pubmed:25947168
• pubmed:2775266
• pubmed:7606467
• pubmed:9316402
• reaxys:8184948

Ontology

ChEBI  ( EBI )

Resources

CTD