Search Ontology:
ChEBI

pexidartinib

Term ID
CHEBI:145373
Synonyms
  • 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
  • CML-261
  • pexidartinib
  • pexidartinibum
  • PLX-3397
  • PLX3397
  • Turalio
(all 7)
Definition
A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
References
(all 19)
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from pexidartinib
Phenotype where environments contain pexidartinib
Phenotype modified by environments containing pexidartinib
Phenotype affecting pexidartinib
Human Disease Model
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