Search Ontology:
ChEBI
gilteritinib
- Term ID
- CHEBI:145372
- Synonyms
-
- 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-2-pyrazinecarboxamide
- 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide
- 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-[(oxan-4-yl)amino]pyrazine-2-carboxamide
- ASP 2215
- ASP-2215
- ASP2215
- gilteritinib
- gilteritinibum
- Xospata
- Definition
- A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.
- References
-
- cas:1254053-43-4
- drugbank:DB12141
- kegg.drug:D10709
- pmc:PMC6817455
- pubmed:26279055
- pubmed:27908881
- pubmed:28516360
- pubmed:28645776
- pubmed:29498296
- pubmed:30039554
- pubmed:30514344
- pubmed:30721452
- pubmed:30936061
- pubmed:31069015
- pubmed:31122910
- pubmed:31203997
- pubmed:31320594
- pubmed:31454267
- pubmed:31469903
- pubmed:31528345
- pubmed:31665578
- pubmed:31692922
- wikipedia.en:Gilteritinib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from gilteritinib
Phenotype where environments contain gilteritinib
Phenotype modified by environments containing gilteritinib
Phenotype affecting gilteritinib
Human Disease Model