crenolanib

Term ID

CHEBI:145365

Synonyms

1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine
1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine
1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine
1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
ARO 002
ARO-002
CP 868596
CP-868,596
CP-868596
CP868569
crenolanib
crenolanibum

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopiperidine aromatic ether benzimidazoles oxetanes quinolines ... Show All 6 Terms

aminopiperidine aromatic ether benzimidazoles oxetanes quinolines tertiary amino compound Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from crenolanib

Phenotype where environments contain crenolanib

Phenotype modified by environments containing crenolanib

Human Disease Model