andrastin A

Term ID

CHEBI:142842

Synonyms

methyl (3beta,5beta,8alpha,9beta,10alpha,13alpha)-3-acetoxy-15-hydroxy-4,4,8,12,16-pentamethyl-17,19-dioxoandrosta-11,15-diene-14-carboxylate
methyl 3beta-acetoxy-15-hydroxy-4,4,8alpha,12,16-pentamethyl-17,19-dioxo-5beta,9beta,10alpha,13alpha-androsta-11,15-diene-14-carboxylate

Definition

A 19-oxo steroid that is that is andrastin B in which the hydroxy group at position 19 has been oxidised to give the corresponding aldehyde. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 5beta steroid 15-hydroxy steroid 17-oxo steroid 19-oxo steroid acetate ester ... Show All 9 Terms

5beta steroid 15-hydroxy steroid 17-oxo steroid 19-oxo steroid acetate ester enol meroterpenoid methyl ester steroid aldehyde Show first 5 Terms
has_functional_parent: andrastin B

andrastin B Show first 5 Terms
has_role: EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite

EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite Show first 5 Terms
inverse is_conjugate_base_of: andrastin A(1-)

andrastin A(1-) Show first 5 Terms
is_conjugate_acid_of: andrastin A(1-)

andrastin A(1-) Show first 5 Terms

Phenotype

Phenotype resulting from andrastin A

Phenotype where environments contain andrastin A

Phenotype modified by environments containing andrastin A

Human Disease Model