Search Ontology:
ChEBI
tyloxapol
- Term ID
- CHEBI:141517
- Synonyms
-
- 4-(1,1,2,2-tetramethylbutyl)phenol polyer with formaldehyde and oxirane
- Alevaire
- oxyethylated tertiary octylphenol formaldehyde polymer
- p-(1,1,3,3-tetramethylbutyl)phenol polymer with ethylene oxide and formaldehyde
- p-isooctylpolyoxyethylenenphenol formaldehyde polymer
- Superinone
- tiloxapol
- Triton A-20
- Triton WR-1339
- tyloxapol
- tyloxapolum
- tyloxypal
- Definition
- A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.
- References
-
- cas:25301-02-4
- drugbank:DB06439
- drugcentral:4738
- kegg.drug:D03261
- patent:EP0602702
- patent:US2454541
- pubmed:16779702
- pubmed:25182386
- pubmed:26949944
- pubmed:27308826
- pubmed:27504278
- pubmed:27558168
- pubmed:28432556
- pubmed:28684216
- pubmed:28961514
- pubmed:30182365
- pubmed:30270241
- wikipedia.en:Tyloxapol
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from tyloxapol
Phenotype where environments contain tyloxapol
Phenotype modified by environments containing tyloxapol
Phenotype affecting tyloxapol
Human Disease Model