6beta-hydroxycortisol

Term ID

CHEBI:139271

Synonyms

(6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione
6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione
6beta-HO-cortisol
6beta-hydroxycortisol
6beta-OH-cortisol
NSC 76163

Definition

A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 3-oxo-Delta(4) steroid 6beta-hydroxy steroid 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid ... Show All 9 Terms

3-oxo-Delta(4) steroid 6beta-hydroxy steroid 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid C21-steroid primary alpha-hydroxy ketone tertiary alpha-hydroxy ketone Show first 5 Terms
has_functional_parent: cortisol

cortisol Show first 5 Terms
has_role: human metabolite mammalian metabolite probe

human metabolite mammalian metabolite probe Show first 5 Terms

Phenotype

Phenotype resulting from 6beta-hydroxycortisol

Phenotype where environments contain 6beta-hydroxycortisol

Phenotype modified by environments containing 6beta-hydroxycortisol

Human Disease Model