Search Ontology:
ChEBI
6beta-hydroxycortisone
- Term ID
- CHEBI:139269
- Synonyms
-
- 6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione
- 6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione
- 6beta-hydroxycortisone
- Definition
- A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6β-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
- References
-
- pubmed:10718654
- pubmed:13941685
- pubmed:21490593
- reaxys:3177303
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from 6beta-hydroxycortisone
Phenotype where environments contain 6beta-hydroxycortisone
Phenotype modified by environments containing 6beta-hydroxycortisone
Phenotype affecting 6beta-hydroxycortisone
Human Disease Model