Search Ontology:
ChEBI

3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide

Term ID
CHEBI:138438
Synonyms
  • 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
  • 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
  • SAG
  • SG8
Definition
A member of the class of 1-benzothiophenes that is 3-chloro-1-benzothiophene-2-carboxamide in which the amide nitrogen is substituted by trans-4-(methylamino)cyclohexyl and 3-(pyridin-4-yl)benzyl groups. A smoothened (Smo) receptor agonist that antagonizes cyclopamine action at the Smo receptor. Activates the Hedgehog signaling pathway in a Patched independent manner.
References
  • cas:912545-86-9
  • pdb-ccd:SG8
  • pubmed:20600593
  • pubmed:22013124
  • pubmed:23981360
  • pubmed:24005160
  • pubmed:27241024
  • pubmed:27672740
  • pubmed:27702396
  • pubmed:27801979
  • pubmed:28198775
  • pubmed:28538564
  • wikipedia.en:Smoothened_agonist
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Phenotype where environments contain 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Phenotype modified by environments containing 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Phenotype affecting 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Human Disease Model