Search Ontology:
ChEBI
Z-DEVD-FMK
- Term ID
- CHEBI:138013
- Synonyms
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- benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
- benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone
- methyl (4S)-5-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-4-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoyl]amino}-5-oxopentanoate
- methyl (5S,8S,11S,14S)-14-(fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
- N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester
- specific inhibitor of caspase-3
- Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
- Z-DEVD-fluoromethylketone
- Definition
- A tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10.
- References
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from Z-DEVD-FMK
Phenotype where environments contain Z-DEVD-FMK
Phenotype modified by environments containing Z-DEVD-FMK
Human Disease Model