Search Ontology:
ChEBI

venetoclax

Term ID
CHEBI:133021
Synonyms
  • 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
  • ABT 199
  • ABT-199
  • ABT199
  • GDC 0199
  • Venclexta
  • venetoclax
Definition
A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.
References
  • cas:1257044-40-8
  • drugcentral:5133
  • kegg.drug:D10679
  • pubmed:24794804
  • pubmed:25185206
  • pubmed:25658896
  • pubmed:25768998
  • pubmed:25829398
  • pubmed:25882699
  • pubmed:25957396
  • pubmed:26110568
  • pubmed:26467384
  • pubmed:26493374
  • pubmed:26516589
  • pubmed:26565405
  • pubmed:26589495
  • pubmed:26711339
  • pubmed:26927160
  • pubmed:26967820
  • pubmed:27030982
  • pubmed:27056887
  • pubmed:27092880
  • pubmed:27095788
  • pubmed:27103402
  • pubmed:27166183
  • pubmed:27283158
  • pubmed:27466751
  • pubmed:27480872
  • reaxys:20908256
  • wikipedia.en:Venetoclax
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from venetoclax
Phenotype where environments contain venetoclax
Phenotype modified by environments containing venetoclax
Phenotype affecting venetoclax
Human Disease Model