losmapimod

Term ID

CHEBI:131167

Synonyms

• 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
• 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide
• 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
• 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
• 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
• FTX 1821
• FTX1821
• GSK-AHAB
• GSKAHAB
• GW 856553
• GW 856553X
• GW-856553X
• GW856553
• GW856553X
• losmapimod
• losmapimodum
• SB 856553
• SB856553

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]pyridine-3-carboxylic acid with the amino group of neopentylamine. It is a potent p38alpha/beta mitogen activated protein kinase inhibitor which was previously in clinical trials for the treatment of facioscapulohumeral muscular dystrophy -- trial now discontinued due to not achieving its primary endpoint.

References

• CAS:585543-15-3
• DrugBank:DB12270
• HMDB:HMDB0254167
• KEGG:D09639
• LINCS:LSM-42767
• PMCID:PMC7521204
• PMID:19556450
• PMID:23137494
• PMID:23215699
• PMID:23250695
• PMID:24699061
• PMID:24981141
• PMID:25612153
• PMID:26273189
• PMID:27043082
• PMID:27136906
• PMID:27746967
• PMID:29045288
• PMID:29206629
• PMID:29396298
• PMID:29398601
• PMID:29566026
• PMID:30953674
• PMID:31231220
• PMID:32775822
• PMID:33931884
• PMID:37439223
• PMID:37588580
• PMID:38631764
• PMID:38959779
• PMID:39000409
• PMID:39146767
• PMID:40034007
• PMID:40580827
• Wikipedia:Losmapimod

Ontology

ChEBI  ( EBI )