plerixafor

Term ID

CHEBI:125354

Synonyms

• 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane)
• 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane)
• 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
• AMD 3100
• AMD-3100
• AMD3100
• JKL 169
• JM3100
• Mozobil
• plerixafor
• plerixaforum
• SDZ SID 791

Definition

An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

References

• cas:110078-46-1
• drugbank:DB06809
• drugcentral:4410
• hmdb:HMDB0015681
• kegg.drug:D08971
• lincs.smallmolecule:LSM-36826
• pubmed:17324009
• pubmed:18847313
• pubmed:24179472
• pubmed:26106388
• pubmed:26154069
• pubmed:26600122
• pubmed:27575003
• pubmed:28411174
• pubmed:29461034
• pubmed:30037618
• pubmed:30290049
• pubmed:30422351
• pubmed:30776910
• pubmed:7913308
• wikipedia.en:Plerixafor

Ontology

ChEBI  ( EBI )