Search Ontology:
ChEBI
GSK126
- Term ID
- CHEBI:124921
- Synonyms
-
- (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide
- GSK 126
- Definition
- A member of the class of methylindoles that is 1H-indole substituted by (2S)-butan-2-yl, methyl, N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]acetamide, and 6-(piperazin-1-yl)pyridin-3-yl groups at positions 1, 3, 4, and 6, respectively. It is a potent and highly selective inhibitor of EZH2 methyltransferase (IC50 = 9.9 nM).
- References
-
- CAS:1346574-57-9
- LINCS:LSM-36365
- PDBeChem:A9G
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
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Phenotype
Phenotype resulting from GSK126
Phenotype where environments contain GSK126
Phenotype modified by environments containing GSK126
Phenotype affecting GSK126
Human Disease Model