Gene

htt

ID
ZDB-GENE-990415-131
Name
huntingtin
Symbol
htt Nomenclature History
Previous Names
  • etID309952.1 (1)
  • hd (1)
  • ZHD (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Involved in several processes, including chordate embryonic development; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to cytoplasm and nucleus. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Is expressed in brain; head; intermediate cell mass of mesoderm; and post-vent region. Orthologous to human HTT (huntingtin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htt Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Huntington's disease Alliance Huntington disease 143100
Lopes-Maciel-Rodan syndrome 617435
Associated With htt Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000091 Huntingtin
Family IPR028426 Huntingtin family
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold Huntingtin Huntingtin family
UniProtKB:A0A8M3AU50 3169
UniProtKB:A0A8M2B6V6 3115
UniProtKB:A0A8M3AIU2 3106
UniProtKB:A0A8M3B295 3178
UniProtKB:A0A8M3AIT6 3184
UniProtKB:O42269 3121
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations