ZFIN Person: Astin, Jonathan

ZFIN ID: ZDB-PERS-160212-1

Astin, Jonathan

Email:	j.astin@auckland.ac.nz
URL:
Affiliation:	Astin Lab
Address:	Department of Molecular Medicine and Pathology Faculty of Medical and Health Sciences The University of Auckland 85 Park Road, Grafton 1023 Auckland, New Zealand
Country:	New Zealand
Phone:	+64 9 923 4480
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Ng, M.F., Da Silva Viana, J., Tan, P.J., Britto, D.D., Choi, S.B., Kobayashi, S., Samat, N., Song, D.S.S., Ogawa, S., Parhar, I.S., Astin, J.W., Hogan, B.M., Patel, V., Okuda, K.S. (2024) Canthin-6-One Inhibits Developmental and Tumour-Associated Angiogenesis in Zebrafish. Pharmaceuticals (Basel, Switzerland). 17(1):

Darroch, H., Astin, J.W., Hall, C.J. (2023) Microinjection of β-glucan Into Larval Zebrafish (Danio rerio) for the Assessment of a Trained-Like Immunity Phenotype. Bio-protocol. 13:e4888e4888

Riisom, M., Morrow, S.J., Herbert, C.D., Tremlett, W.D.J., Astin, J.W., Jamieson, S.M.F., Hartinger, C.G. (2023) In vitro and in vivo accumulation of the anticancer Ru complexes [Ru^II(cym)(HQ)Cl] and [Ru^II(cym)(PCA)Cl]Cl. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 28(8):767-775

Darroch, H., Keerthisinghe, P., Sung, Y.J., Rolland, L., Prankerd-Gough, A., Crosier, P.S., Astin, J.W., Hall, C.J. (2023) Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity. Science advances. 9:eadf9904eadf9904

Sullivan, M.P., Adams, M., Riisom, M., Herbert, C.D., Tong, K.K.H., Astin, J.W., Jamieson, S.M.F., Hanif, M., Goldstone, D.C., Hartinger, C.G. (2023) Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo. Dalton transactions (Cambridge, England : 2003). 52(5):1388-1392

Linnerz, T., Sung, Y.J., Rolland, L., Astin, J.W., Dalbeth, N., Hall, C.J. (2022) Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence. Genes. 13(12):

Britto, D.D., He, J., Misa, J.P., Chen, W., Kakadia, P.M., Grimm, L., Herbert, C.D., Crosier, K.E., Crosier, P.S., Bohlander, S.K., Hogan, B.M., Hall, C.J., Torres-Vázquez, J., Astin, J.W. (2022) Plexind1 negatively regulates zebrafish lymphatic development. Development (Cambridge, England). 149(21)

Hall, C.J., Astin, J.W., Mumm, J.S., Ackerley, D.F. (2022) A New Transgenic Line for Rapid and Complete Neutrophil Ablation. Zebrafish. 19(3):109-113

Darroch, H., Astin, J.W., Hall, C.J. (2022) Towards a new model of trained immunity: Exposure to bacteria and β-glucan protects larval zebrafish against subsequent infections. Developmental and comparative immunology. 132:104400

Hanif, M., Arshad, J., Astin, J., Rana, Z., Zafar, A., Movassaghi, S., Leung, E., Patel, K., Soehnel, T., Reynisson, J., Sarojini, V., Rosengren, R., Jamieson, S., Hartinger, C. (2020) A Multitargeted Approach in the Discovery of an Organorhodium Anticancer Agent Based On Vorinostat as a Potent Histone Deacetylase Inhibitor. Angewandte Chemie (International ed. in English). 59(34):14609-14614

Linnerz, T., Kanamala, M., Astin, J.W., Dalbeth, N., Wu, Z., Hall, C.J. (2020) Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes. Journal of visualized experiments : JoVE. (156):

Parveen, S., Hanif, M., Leung, E., Tong, K.K.H., Yang, A., Astin, J., De Zoysa, G.H., Steel, T.R., Goodman, D., Movassaghi, S., Söhnel, T., Sarojini, V., Jamieson, S.M.F., Hartinger, C.G. (2019) Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity. Chemical communications (Cambridge, England). 55(80):12016-12019

Britto, D.D., Hall, C.J., Astin, J.W. (2019) In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts. Journal of visualized experiments : JoVE. (150):

Eng, T.C., Chen, W., Okuda, K.S., Misa, J.P., Padberg, Y., Crosier, K.E., Crosier, P.S., Hall, C.J., Schulte-Merker, S., Hogan, B.M., Astin, J.W. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports. 20(5):

Wu, Z., Koh, B., Lawrence, L.M., Kanamala, M., Pool, B., Svirskis, D., Dalbeth, N., Astin, J.W., Crosier, K.E., Crosier, P.S., Hall, C.J. (2019) Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function. Zebrafish. 16(2):171-181

Britto, D.D., Wyroba, B., Chen, W., Lockwood, R.A., Tran, K.B., Shepherd, P.R., Hall, C.J., Crosier, K.E., Crosier, P.S., Astin, J.W. (2018) Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease models & mechanisms. 11(12):

Hall, C.J., Sanderson, L.E., Lawrence, L.M., Pool, B., van der Kroef, M., Ashimbayeva, E., Britto, D., Harper, J.L., Lieschke, G.J., Astin, J.W., Crosier, K.E., Dalbeth, N., Crosier, P.S. (2018) Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of Clinical Investigation. 128(5):1752-1771

Eng, T.C.Y., Astin, J.W. (2018) Characterization of Zebrafish Facial Lymphatics. Methods in molecular biology (Clifton, N.J.). 1846:71-83

Du, L.Y., Darroch, H., Keerthisinghe, P., Ashimbayeva, E., Astin, J.W., Crosier, K.E., Crosier, P.S., Warman, G., Cheeseman, J., Hall, C.J. (2017) The innate immune cell response to bacterial infection in larval zebrafish is light-regulated. Scientific Reports. 7:12657

Astin, J.W., Keerthisinghe, P., Du, L., Sanderson, L.E., Crosier, K.E., Crosier, P.S., Hall, C.J. (2017) Innate immune cells and bacterial infection in zebrafish. Methods in cell biology. 138:31-60

Astin, J.W., Crosier, P.S. (2016) Lymphatics, Cancer and Zebrafish. Advances in experimental medicine and biology. 916:199-218

NON-ZEBRAFISH PUBLICATIONS