| Name: |
canonical Wnt signaling pathway |
| Synonyms: |
canonical Wnt receptor signaling pathway,
canonical Wnt-activated signaling pathway,
frizzled-1 receptor signaling pathway,
Wnt receptor signaling pathway through beta-catenin,
Wnt receptor signaling pathway via beta-catenin,
Wnt receptor signalling pathway through beta-catenin
|
| Definition: |
A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| Ontology: |
GO: Biological Process [GO:0060070]
QuickGO
AmiGO
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