OBO ID: GO:0140467
Term Name: integrated stress response signaling Search Ontology:
  • ISR
Definition: The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. 27629041
Ontology: GO: Biological Process   QuickGO   AmiGO
PHENOTYPE No data available