| OBO ID: GO:0097452 |
| Term Name: | GAIT complex | Search Ontology: | |
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| Definition: | A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. (2) | ||
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| Ontology: | GO: Cellular Component QuickGO AmiGO |
Show first 5 Terms
EXPRESSION
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PHENOTYPE
No data available