OBO ID: GO:0070375
Term Name: ERK5 cascade Search Ontology:
Synonyms:
  • big MAP kinase signaling cascade
  • BMK cascade
  • BMK signaling pathway
  • BMK signalling pathway
  • BMK1 cascade
  • ERK5 signaling pathway
  • extracellular signal-regulated kinase 5 cascade
  • MAPK7 cascade
Definition: A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development. (5)
References:
Ontology: GO: Biological Process    QuickGO    AmiGO
PHENOTYPE No data available