OBO ID: GO:0070266

Term Name:	necroptotic process		Search Ontology:
Synonyms:	activation of necroptosis activation of necroptosis by extracellular signals activation of necroptosis in response to extracellular signals activation of necroptosis of activated-T cells establishment of necroptosis establishment of necroptosis of activated-T cells extracellular signal-induced necroptosis induction of necroptosis induction of necroptosis by extracellular signals induction of necroptosis of activated-T cells necroptosis PARP-dependent cell death parthanatos programmed necrosis programmed necrotic cell death RIPK1-mediated regulated necrosis TNF-induced necroptosis
Definition:	A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. (5)
References:
Ontology:	GO: Biological Process    QuickGO    AmiGO