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ZIRC
OBO ID: GO:0043224
Term Name: nuclear SCF ubiquitin ligase complex Search Ontology:
Synonyms:
  • nuclear cullin complex
  • nuclear SCF complex
  • nuclear Skp1/Cul1/F-box protein complex
Definition: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (2)
References:
Ontology: GO: Cellular Component   QuickGO   AmiGO
EXPRESSION No data available
PHENOTYPE No data available