| Term Name: |
broad specificity oxidative DNA demethylase activity |
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Search Ontology:
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| Synonyms: |
- 1-ethyladenine demethylase activity
- 2-oxoglutarate-dependent DNA demethylase
- 5-formylcytosine dioxygenase activity
- 5-hydroxymethylcytosine dioxygenase activity
- N1-methyladenine demethylase activity
- N3-methylcytosine demethylase activity
- oxidative DNA demethylase activity
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| Definition: |
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
(4)
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| References: |
- EC:1.14.11.33
- MetaCyc:RXN-12353
- RHEA:30299
- Reactome:R-HSA-112118
- Reactome:R-HSA-112123
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| Ontology: |
GO: Molecular Function
QuickGO
AmiGO
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