| Term Name: |
Notch receptor processing, ligand-dependent |
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Search Ontology:
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| Synonyms: |
- Notch S2 cleavage
- Notch S3 cleavage
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| Definition: |
The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
12651094
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| References: |
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| Ontology: |
GO: Biological Process
QuickGO
AmiGO
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