OBO ID: GO:0019907 |
Term Name: | cyclin-dependent protein kinase activating kinase holoenzyme complex | Search Ontology: | |
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Definition: | A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. 8752210 | ||
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Ontology: | GO: Cellular Component QuickGO AmiGO |
EXPRESSION
No data available
PHENOTYPE
No data available