OBO ID: GO:0007249
Term Name: I-kappaB kinase/NF-kappaB signaling Search Ontology:
  • activation of the inhibitor of kappa kinase
  • canonical NF-kappaB signaling cascade
  • I-kappaB kinase/NF-kappaB cascade
  • I-kappaB kinase/NF-kappaB signal transduction
  • NF-kappaB cascade
  • p50-dependent NF-kappaB signaling
Definition: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 12773372
Ontology: GO: Biological Process   QuickGO   AmiGO
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