OBO ID: GO:0003713

Term Name:	transcription coactivator activity		Search Ontology:
Synonyms:	RNA polymerase II transcription co-activator activity RNA polymerase II transcription coactivator activity RNA polymerase II transcription mediator activity transcription co-activator activity
Definition:	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. (2)
References:
Ontology:	GO: Molecular Function    QuickGO    AmiGO