OBO ID: DOID:3083
Term Name: chronic obstructive pulmonary disease Search Ontology:
Synonyms:
  • chronic obstructive airway disease
  • chronic obstructive lung disease
  • COLD
  • COPD
Definition: An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. (4)
References:
Ontology: Human Disease   ( DOID:3083 )
Relationships
is a type of:
has subtype:
OTHER chronic obstructive pulmonary disease PAGES
GENES INVOLVED
Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID
HMOX1 {Pulmonary disease, chronic obstructive, susceptibility to} 606963
MMP1 COPD, rate of decline of lung function in
ZEBRAFISH MODELS No data available
PHENOTYPE No data available

CITATIONS (2)
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