Term Name: |
cobimetinib |
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Search Ontology:
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Synonyms: |
- [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
- cobimetinib
- GDC 0973
- GDC-0973
- GDC0973
- RG 7420
- RG7420
- Xl 518
- Xl-518
- XL518
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Definition: |
A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.
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References: |
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Ontology: |
ChEBI
(
EBI
)
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