| Term Name: |
rac-selisistat |
|
Search Ontology:
|
| Synonyms: |
- EX-527
- rac-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
- rac-EX-527
- salisistat
- selisistat
- selisistatum
|
| Definition: |
A racemate comprising equimolar amounts of (R)- and (S)-selisistat. It is a potent sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) and is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. The active isomer (EX-243) gives similar results and potency; the enantiomer (EX-242) is inactive.
|
| References: |
|
| Ontology: |
ChEBI
(
EBI
)
|
Show first 5 Terms
