ZFIN ChEBI: naloxone

OBO ID: CHEBI:7459

Term Name:	naloxone		Search Ontology:
Synonyms:	(-)-naloxone 1-N-Allyl-14-hydroxynordihydromorphinone 17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one naloxona naloxone naloxonum
Definition:	A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
References:	Beilstein:1089071 CAS:465-65-6 DrugBank:DB01183 Drug_Central:1878 HMDB:HMDB0015314 KEGG:C07252 KEGG:D08249 LINCS:LSM-3504 PMID:17023477 PMID:24868924 PMID:25468814 PMID:26469689 PMID:26604818 PMID:26634308 Patent:GB939287 Patent:US3254088 Reaxys:1089071 Wikipedia:Naloxone
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	morphinane alkaloid organic heteropentacyclic compound tertiary alcohol morphinane alkaloid organic heteropentacyclic compound tertiary alcohol Show first 5 Terms
has_parent_hydride:	morphinan morphinan Show first 5 Terms
has_role:	antidote to opioid poisoning central nervous system depressant mu-opioid receptor antagonist antidote to opioid poisoning central nervous system depressant mu-opioid receptor antagonist Show first 5 Terms
inverse has_functional_parent:	naloxegol naloxegol Show first 5 Terms
inverse is_conjugate_acid_of:	naloxone(1+) naloxone(1+) Show first 5 Terms
is_conjugate_base_of:	naloxone(1+) naloxone(1+) Show first 5 Terms

PHENOTYPE No data available