| Term Name: |
4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol |
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Search Ontology:
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| Synonyms: |
- 1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole
- 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol
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| Definition: |
A pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.
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| References: |
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| Ontology: |
ChEBI
(
EBI
)
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