ZFIN ChEBI: 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide

OBO ID: CHEBI:64101

Term Name:	4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide		Search Ontology:
Synonyms:	4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide S 14506 S-14506 S14506
Definition:	A benzamide obtained by formal condensation of the carboxy group of 4-fluorobenzoic acid with the primary amino group of 2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethylamine. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
References:	LINCS:LSM-3034 PMID:10867965 PMID:11104831 PMID:11159702 PMID:11166326 PMID:19605522 PMID:20657759 PMID:7667330 PMID:7705455 PMID:8539317 PMID:8905325 Patent:US5143916 Reaxys:8167507
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	benzamides methoxynaphthalene N-alkylpiperazine N-arylpiperazine organofluorine compound benzamides methoxynaphthalene N-alkylpiperazine N-arylpiperazine organofluorine compound Show first 5 Terms
has_role:	anxiolytic drug serotonergic agonist anxiolytic drug serotonergic agonist Show first 5 Terms
inverse is_conjugate_acid_of:	4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+) 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+) Show first 5 Terms
is_conjugate_base_of:	4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+) 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+) Show first 5 Terms

PHENOTYPE No data available