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OBO ID: CHEBI:64086
Term Name: vanoxerine dihydrochloride Search Ontology:
Synonyms:
  • 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride
  • 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazinediium dichloride
  • GBR 12909 dihydrochloride
  • GBR12909 dihydrochloride
  • Vanoxerine hydrochloride
Definition: A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
References:
Ontology: Chebi
PHENOTYPE No data available