| Term Name: |
vanoxerine dihydrochloride |
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Search Ontology:
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| Synonyms: |
- 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride
- 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazinediium dichloride
- GBR 12909 dihydrochloride
- GBR12909 dihydrochloride
- Vanoxerine hydrochloride
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| Definition: |
A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
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| References: |
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| Ontology: |
ChEBI
(
EBI
)
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