OBO ID: CHEBI:6076

Term Name:	itraconazole		Search Ontology:
Synonyms:	2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one Itraconazole Itrizole (TN) Oriconazole Sporanox (TN)
Definition:	An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
References:	CAS:84625-61-6 DrugBank:DB01167 KEGG:D00350 PMID:11219548 PMID:11403818 PMID:11422002 PMID:15521894 PMID:19025521 PMID:20400651 PMID:25326091 Patent:EP6711 Patent:US4267179 VSDB:1853 Wikipedia:Itraconazole
Ontology:	ChEBI  ( EBI )