OBO ID: CHEBI:5971

Term Name:	irinotecan hydrochloride (anhydrous)		Search Ontology:
Synonyms:	(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride 1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxy camptothecin hydrochloride Camptothecin 11 hydrochloride CPT 11 CPT-11 Irinotecan HCl Irinotecan hydrochloride irinotecan monohydrochloride U 101440E
Definition:	A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
References:	CAS:100286-90-6 DrugBank:DB00762 PMID:24474168 PMID:25142792 PMID:25233635 PMID:25512111 PMID:25750295 PMID:26309154 PMID:26352218 PMID:26422291 PMID:26526067 PMID:26540095 PMID:26604633 Reaxys:4837793 Wikipedia:Irinotecan
Ontology:	ChEBI  ( EBI )