OBO ID: CHEBI:49490

Term Name:	AZD7545		Search Ontology:
Synonyms:	(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide 4-(3-chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}benzene-1-sulfonyl)-N,N-dimethylbenzamide 4-[(3-chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}phenyl)sulfonyl]-N,N-dimethylbenzamide AZD 7545 AZD-7545
Definition:	A sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM).
References:	CAS:252017-04-2 Chemspider:20572552 DrugBank:DB07403 LINCS:LSM-6250 PDBeChem:AZX PMID:14641018 PMID:14641019 PMID:17602666 PMID:17683942 PMID:18658136 PMID:27757958 PMID:28199108 PMID:28595656 PMID:30028142 PMID:30597326 PMID:31495556 PMID:33125772
Ontology:	ChEBI  ( EBI )