OBO ID: CHEBI:47344
Term Name: alvocidib Search Ontology:
Synonyms:
  • (-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one
  • alvocidib
  • alvocidibum
  • Flavopiridol
  • HMR 1274
  • HMR-1274
  • L 86-8275
  • L 868275
  • L-868275
  • L86-8275
Definition: A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
References:
Ontology: Chebi
PHENOTYPE No data available