ZFIN ChEBI: digoxin

OBO ID: CHEBI:4551

Term Name:	digoxin		Search Ontology:
Synonyms:	(3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide 12beta-hydroxydigitoxin digoxin
Definition:	A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
References:	Beilstein:77011 CAS:20830-75-5 DrugBank:DB00390 Drug_Central:882 KEGG:C06956 KEGG:D00298 KNApSAcK:C00003618 PDB:1IGJ PDBeChem:DGX PMID:10438974 PMID:16970134 PMID:7739045 PMID:8234291 Reaxys:77011 Wikipedia:Digoxin
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	cardenolide glycoside steroid saponin cardenolide glycoside steroid saponin Show first 5 Terms
has_role:	anti-arrhythmia drug cardiotonic drug EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor epitope anti-arrhythmia drug cardiotonic drug EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor epitope Show first 5 Terms
inverse has_functional_parent:	12-O-acetyldigoxin 20,22-dihydrodigoxin 12-O-acetyldigoxin 20,22-dihydrodigoxin Show first 5 Terms
inverse is_conjugate_base_of:	digoxin(1-) digoxin(1-) Show first 5 Terms
is_conjugate_acid_of:	digoxin(1-) digoxin(1-) Show first 5 Terms

PHENOTYPE No data available