Term Name: |
SYC-435 |
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Search Ontology:
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Synonyms: |
- 1-hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
- 1-hydroxy-4-methyl-6-benzyl-2(1H)-pyridone
- 6-benzyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
- 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
- 6-benzyl-1-hydroxy-4-methylpyridin-2-one
- 6-benzyl-4-methyl-1-hydroxypyridin-2(1H)-one
- SYC 435
- SYC435
- TC-E 5008
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Definition: |
A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).
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References: |
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Ontology: |
ChEBI
(
EBI
)
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