ZFIN ChEBI: mefuparib

OBO ID: CHEBI:167905

Term Name:	mefuparib		Search Ontology:
Synonyms:	5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide CVL-218 free base
Definition:	A member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19.
References:	CAS:1392502-82-7 Drug_Central:5378 PMID:27926532 PMID:31671946 PMID:32984792 PMID:33063092 PMID:33151287
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	1-benzofurans organofluorine compound primary carboxamide secondary amino compound 1-benzofurans organofluorine compound primary carboxamide secondary amino compound Show first 5 Terms
has_role:	anticoronaviral agent antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor anticoronaviral agent antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of:	mefuparib(1+) mefuparib(1+) Show first 5 Terms
is_conjugate_base_of:	mefuparib(1+) mefuparib(1+) Show first 5 Terms

PHENOTYPE No data available