OBO ID: CHEBI:167707

Term Name:	acalabrutinib		Search Ontology:
Synonyms:	(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(2-pyridyl)benzamide 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide acalabrutinib acalabrutinibum ACP-196 Calquence
Definition:	A member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.
References:	CAS:1420477-60-6 Chemspider:36764951 DrugBank:DB11703 Drug_Central:5260 KEGG:D10893 PMID:26641137 PMID:26957112 PMID:28642301 PMID:28882879 PMID:30664965 PMID:30681658 PMID:30967367 PMID:31306750 PMID:31355927 PMID:31686856 PMID:31738609 PMID:31866282 PMID:31915195 PMID:32202637 PMID:32256115 PMID:32305083 PMID:32358576 PMID:32675912 PMID:32678359 PMID:32757302 PMID:33032842 PMID:33216986 PMID:33322571 PMID:33427570 PMID:33441177 PMID:33486852 PMID:33491779 PMID:33526860 PMID:33613932 PMID:33728735 PMID:33730844 Wikipedia:Acalabrutinib
Ontology:	ChEBI  ( EBI )